Final Program

thursday
friday
saturday

Thursday, November 10^th

Prognosis in Head and Neck Squamous Cell Cancer

08:00-08:50   Registration and coffee

Opening
Lecture hall 1

08:50  : Robert J. Baatenburg de Jong

Plenary session I Patient and tumor factors in prognosis
Lecture hall 1

Keynote presentations
Chair: C. René Leemans

09:00 Luiz P. Kowalski: General tumor factors
09:30 Jay F. Piccirillo: Co-morbidity
10:00 Marciano B. Ferrier: Prior tumors and survival

10:30-11:00  Coffee break

Keynote presentations (continued)

11:00  Hisham Mehanna: Quality of life and psychologic factors
11:30 Christopher O'Brien: Prognostic factors in oral cancer

Oral presentations
Chair: Alphons J.M. Balm

12:00  R.J. Shaw: What is the influence of site on prognosis in oral & oropharyngeal cancer?
12:10 S.F. Hall: Prognostic factors in cancer of the hypopharynx
12:20 I. Adam: Survival of young patients with oral cancer
12:30 R. de Bree: The prognostic importance of paratracheal lymph node metastases
12:40 R.J. Shaw: The influence of the pattern of mandibular invasion on prognosis  in oral squamous cell carcinoma

  Lunch 12:50-14:00

Plenary session II Immunology, histopathology and markers in prognosis
Lecture hall 1

Keynote presentations
Chair: Michiel W.M. van den Brekel

14:00  Theresa L. Whiteside: Immunology
14:30  Jon Sudbø: Prevention-therapy convergence and the oral intraepithelial neoplasia model
15.00  Loes M.L.W. van Velthuysen: Histopathology and markers
15:30  Robert P. Takes: Prediction of metastasis
16:00-16:30 Tea break

Parallel session A
Lecture hall 1

Oral presentations
Chair: Robert P. Takes

16.30  E.M.D. Schuuring: Amplification of 11q13 leads to increased expression of FADD in head and neck squamous cell carcinomas
16:40  C.H. Kim: Effect of hepatocyte growth factor on E-cadherin in hypopharyngeal cancer
16:50  S. Nuyts: The prognostic value of hypoxia and microsatellite alterations in head and neck cancer
17:00  C. Liew: The characteristics of the resection margin in oral squamous cell carcinoma, and its prognostic and predictive significance
17:10  M. Dutsch-Wicherek: Metallothionein expression in head and neck cancer and its healthy stroma
17:20  M. Dutsch - Wicherek: RCAS1 expression in head and cancer and its clear surgical margin
17.30  G. Bahar: Compromised Salivary Antioxidant, Enzymatic and Immunological Protection in Tongue Cancer Patients

Parallel session B
Lecture hall 3

Oral presentations
Chair: Jan L.N. Roodenburg

16:30  R.J. Shaw: Longitudinal analysis of genetic aberrations in circulating DNA and prognosis in oral cancer
16:40  M.B. Prystowsky: Cytoplasmic EZRIN expression has prognostic significance for head and neck squamous cell carcinoma
16:50  B.M. Erovic: Mcl-1, VEGF-R2 and 14-3-delta expression might predict primary response of (chemo-)radiation in patients with locally advanced squamous cell carcinoma of the head and neck
17:00  F.J.P. Hoebers: Prediction of outcome by cisplatin dna-adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin-chemoradiation (RADPLAT)
17:10  J.M. Middeldorp: Non-invasive diagnosis of nasopharyngeal carcinoma
17:20  J. Klozar: HPV as the risk factor of oral/oropharyngeal cancer
18:30  Reception Burgerzaal City Hall , Breestraat, Leiden

Friday, November 11^th

Prognosis in Head and Neck Squamous Cell Cancer

Plenary session III Imaging and treatment factors in prognosis
Lecture hall 1

Keynote presentations
Chair: Hans A. Langendijk

08:30  Robert Hermans: Imaging of the primary tumor
09:00  Michiel W.M. van den Brekel: Imaging of metastasis
09:30  Patti A. Groome: Treatment factors in prognosis

10:00 – 10:30 Coffee break

Oral presentations
Chair: J.P. Richard van Merkesteyn

10:30  S.C. Ritoe: Effectiveness of routine follow-up after treatment for laryngeal cancer on life expectancy and quality of life: the application of a markov-model
10:40  A. Rosenberg : Prognostic predictive factors of complications in micro-vascular free flap reconstruction for oral and oropharyngeal defects. A single-centre prospective study on 158 patients.
10:50  R. de Bree: Comorbid condition as a prognostic factor for complications and survival in patients with oral and oropharyngeal cancer after surgical treatment with microvascular reconstruction
11:00  C.A. Szymczyk: Multivariate analysis of prognostic and predictive factors for lip cancer patients related to three different treatment modalities
11:10  P. Silva: Factors influencing prognosis in a homogenous group of head and neck squamous cell carcinoma patients treated with radiotherapy

11:20 – 13:30 Satellite lunch program: Dynamic Developments in Head & Neck Cancer
Lecture hall 5

 Chair: Bing Tan

12:00  Bing Tan: Clinical view of patients treated with Foscan PDT for Head &Neck Cancer
12:40  Vincent VanderPoorten: Mthpc mediated photodynamic therapy experience in Leuven

Plenary session IV Predictive models in prognosis
Lecture hall 1

Oral presentations
Chair: Patti A.Groome

13:30  J.A. Langendijk: Recursive partitioning analysis in the postoperative setting in squamous cell head and neck cancer: validation of risk group definition in the EORTC 22931 database
13:40  R.W. Nason: Prognosis in oral cancer: beyond clinical staging
13:50  Alyaa Al - Mutairy: Analysis of prognostic factors influencing the outcome of recurrent squamous cell carcinoma in oral cavity: Royal Marsden Hospital experience 1984-2003
14:00  Alyaa Al-Mutairy: Pattern and prognostic factors for recurrence in oropharyngeal squamous cell carcinoma : a review of 224 patients at Royal Marsden Hospital
14:10  M.J.W. Worsham: Developing a protein staging model of early diagnosis in HNSCC

  14:20 – 14:45 Teabreak

Keynote presentations
Chair: J.W. Coebergh

14:45  Saskia le Cessie: Cox models
15:15  Peter van der Putten: Knowledge discovery and data mining
15:45  Jay F. Piccirillo: Prognostogram
16:15  Robert J. Baatenburg de Jong: Oncologiq
16:45  Joost N. Kok: Data fusion: a new tool to fuse prognostic information from different databases
17:15  René Eijkemans: Models and clinical decision making
17:45  Summary and conclusions of Sessions I-IV  

20:00 Congress diner
Location: Kamerlingh Onnes Gebouw, Steenschuur 25, Leiden

Saturday, November 12^th

Parallel session V Prognosis in thyroid cancer
Lecture hall 5

Keynote presentations
Chairs: Henning Dralle / Job Kievit

09:00  Henning Dralle: Prognosis in sporadic and familial medullary thyroid cancer
09:30  Jeremy L. Freeman: Prognosis of differentiated thyroid cancer
10:00  R. Michael Tuttle: Prognosis of thyroid cancer in children and young adults

10:30-11:00 Coffee break

11:00  Job Kievit: Thyroid cancer prognosis; dynamics, impact and decision making

11:30 –14:00 Satellite lunch program  Prognostic factors, prevention and treatment of radiation-induced xerostomia
Lecture hall 1

Chair: Hans A. Langendijk

12:00  C.H. Terhaard: Prognostic factors for radiation-induced xerostomia

12:30  A.P. Jellema: Prevention of radiation-induced xerostomia by amifostine: a prospective randomized study.

13:00  F.R. Burlage: Prevention of radiation-induced xerostomia by pilocarpine: results of a prospective double-blind randomised placebo-controlled study

13:30  R.P. Coppes: Treatment of radiation-induced damage to salivary glands by stem cell transplantation

Parallel session V Prognosis in thyroid cancer (continued)
Lecture hall 5

Free presentations
Chairs: Jeremy L. Freeman / R. Michael Tuttle

14:00  J.Th. John Plukker: Recommendations for the extent of nodal dissection in palpable medullary thyroid cancer
14:15  I.M. Oskam: Neck managemant in medullary thyroid carcinoma
14:30  T.P. Links: Embolization of bone metastases from differentiated thyroid cancer: no effect on life expectancy
14:45  D. Vesely: Production of growth factors in papillary thyroid cancer
15:00 J.Th. John Plukker: Diagnostic value of repeated fine needle aspiration in solitary thyroid nodules
15:15  O.P. Krekhno: Organization of thyroid cancer surgical treatment

 End of Session V Prognosis in thyroid cancer

Keynote presentations
Chair: Vincent VanderPoorten

09:00  Vincent vanderPoorten: Current staging systems
09:30  Christopher O’Brien: Prognostic factors of metastatic cancer in the parotid
10:00  Thomas Löning and Kerstin Roeser: Histopathologic factors and other markers

10:30-11:00 Coffee break

Oral presentations
Chair: Vincent VanderPoorten

11:00  H. Vekony: A gain at chromosome 7q is associated with metastasis in adenoid cystic carcinoma
11:10  H. Vekony: Prognostication of adenoid cystic carcinoma by polycomb group gene expression
11:20  R.W. Nason: Prognosis and clinical decision making in parotid gland malignancy

11:30  - 14:00 Satellite lunch program  Prognostic factors, prevention and treatment of radiation-induced xerostomia
Lecture hall 1

Chair: Hans A. Langendijk

12:00  C.H. Terhaard: Prognostic factors for radiation-induced xerostomia

12:30  A.P. Jellema: Prevention of radiation-induced xerostomia by amifostine: a prospective randomized study.

13:00  F.R. Burlage: Prevention of radiation-induced xerostomia by pilocarpine: results of a prospective double-blind randomised placebo-controlled study

13:30  R.P. Coppes: Treatment of radiation-induced damage to salivary glands by stem cell transplantation

Parallel session VI Prognosis in salivary gland tumors (continued)
Lecture hall 1

Keynote presentations
Chair: Christopher O’Brien

14:00  Luiz P. Kowalski: Predictive factors for neck disease
14:30  Christopher O’Brien: Comparison of primary and secondary parotid malignancies
15:00  Chris H.J. Terhaard: The Dutch Cooperative Group study

15:30 – 16:00 Tea break

Keynote presentations (continued)

16:00  Vincent Vander Poorten: Predictive models
16:30  Jan Willem Coebergh: Clinical decision making

17:00  Closing remarks